Eric Krukonis

Dr. Krukonis obtained his BA in Biology from Rice University in 1990 and his PhD from Tufts University School of Medicine in Molecular Biology and Microbiology in 1997. He then trained as a postdoctoral fellow at the University of Michigan School of Medicine before joining the faculty at the University of Michigan School of Dentistry in 2004. He joined the faculty at the University of Detroit Mercy School of Dentistry in 2013. He teaches microbiology to dental students and dental hygiene students as well as DDS graduates training in various specialties. His research involves uncovering mechanisms of bacterial pathogenesis and regulation of bacterial virulence gene expression.

Selected Publications:

Tsang, T.M., Wiese, J.S., Felek, S. Kronshage, M. and Krukonis, E.S. 2013. Ail proteins of Yersinia pestis and Y. pseudotuberculosis have different cell binding and invasion activities. PLoS One Vol. 8 (12) e83621.

Goss, T.J, Morgan, S.J., French, E.L. and Krukonis, E.S. 2013. ToxR recognizes a direct repeat element in the toxT, ompU, ompT and ctxA promoters of Vibrio cholerae to regulate transcription. Infect. Immun. Vol. 81(3) pp. 884-895.

Tsang, T.M., Annis, D.S., Kronshage, M., Fenno, J.T., Usselman, L.D., Mosher, D.F.,and Krukonis, E.S. 2012. Ail protein binds ninth type III fibronectin repeat (9FNIII) within central 120-kD region of fibronectin to facilitate cell binding by Yersinia pestis. JBC Vol. 287 (20) pp. 16759-16767.

Morgan, S.J., Felek, S., Gadwal, S., Koropatkin, N.M., Perry, W.J., Bryson, A.B., and Krukonis, E.S. 2011. The two faces of ToxR: activator of ompU, co-regulator of toxT in Vibrio cholerae, Mol. Micro. Vol. 81 (1) pp. 113-128.

Felek, S., Jeong, J. J., Runco, L. M., Murray, S., Thanassi, D. and Krukonis, E. S. 2011. Contributions of chaperone/usher systems to cell binding, biofilm formation and Yersinia pestis virulence. Microbiology Vol. 157 (3) pp. 805-818. Cover article

Felek, S., Tsang, T. M.  and Krukonis, E. S. 2010. Three Yersinia pestis adhesins facilitate Yop delivery to eukaryotic cells and contribute to plague virulence. Infect. Immun. Vol. 78 (10) pp. 4134-4150.

Goss, T. J., Seaborn, C. P., Gray, M. D. and Krukonis, E. S. 2010. Identification of the TcpP-binding site in the toxT promoter of Vibrio cholerae and the role of ToxR in TcpP-mediated activation. Infect. Immun. Vol. 78 (10) pp. 4122-4133.

Tsang, T. M., Felek, S. and Krukonis, E. S. 2010. Ail binding to fibronectin facilitates Yersinia pestis binding to host cells and Yop delivery. Infect. Immun. Vol. 78 (8) pp. 3358-3368.

Felek, S. and Krukonis, E.S. 2009. The Yersinia pestis Ail protein mediates binding and Yop delivery to host cells required for plague virulence. Infect. Immun., Vol. 77 (2) pp.825-836.     Cover article